Tech2 news teamMarch 17, 2021 7:13:35 PM IST
In the first case of COVID-19 antibody transfer in utero, a baby was born with antibodies against a vaccinated mother during her pregnancy. The mother is a healthcare worker in Florida, United States, and received her first dose of Moderna vaccine three weeks before giving birth. At the time of vaccination, she was 36 weeks pregnant. The baby girl born in January is vigorous and healthy. The umbilical cord blood was tested and antibodies were detected. The results of the study were published in a pre-print and awaiting peer review.
Two pediatric doctors involved in the study, Drs.Paul Gilbert and Chad Rudnick, say this is the world’s first reported case of anti-COVID-19 antibodies transmitted from vaccinated mother to child. On the other hand, there have been cases of pregnant women infected with SARS-CoV-2 who have also given birth to infected babies. Other reports have shown that recovered mothers can also transmit their antibodies, to their babies.
Dr Gilbert Told WPTV that after the vaccine was released, they started looking for a volunteer who was eligible for the vaccine and who was pregnant. They found a health worker who was able to get the vaccine around the last three months of her pregnancy and then test the umbilical cord.
“To our knowledge, this was the first in the world that has been reported that a baby was born with antibodies after a vaccination,” Gilbert said. The Guardian. “We tested the baby’s cord to see if the mother’s antibodies were passed on to the baby, which we see with other vaccines given during pregnancy. “
Called maternal vaccination, this occurs when a mother transmits certain ‘maternal antibodies’ to the fetus, giving the infant immunity to the disease (in this case, COVID-19). These antibodies are transferred during the last three months of pregnancy, via the placenta. It is also called Passive immunity because the antibodies are given to the baby instead of making them themselves. The vast majority of maternal antibodies are of the IgG isotype.
IgG antibodies stays in the blood after passing an infection. They also indicate a history of vaccination or illness (in this case COVID-19 or vaccination) in the recent past and have developed antibodies that may protect you from future infection.
Pediatricians say they expected the baby to have COVID-19 antibodies and tested the umbilical cord to confirm it. According to pre-print, the “placental passage of antibodies” for influenza and TDaP (Tdap is a combination vaccine that protects against tetanus, diphtheria and pertussis) have been studied to understand the safety and effectiveness of such protection for infants. The researchers believed that “similar protection of the newborn” might be underway after maternal vaccination against SARS-CoV-2.
“This is a small case among thousands and thousands of babies born to mothers who have been vaccinated in the coming months,” Rudnick said.
The study also indicates that certain factors indicate that immunity is not strong – babies born to vaccinated mothers will remain at risk of infection with SARS-CoV-2.
While the new study is an important development in the fight against COVID-19, Rudnick added, further studies need to determine how long this protection can last. “They need to figure out what level of protection or how many antibodies a baby needs to have circulating to give it protection,” he said.
According to WPTV report, doctors hope the discovery will lead to more studies of maternal COVID-19 vaccinations to protect babies.